Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10751196 | Biochemical and Biophysical Research Communications | 2015 | 6 Pages |
Abstract
Scavenger receptor, class B type I (SR-BI) is a physiologically relevant regulator of high density lipoprotein (HDL) metabolism. Low HDL is a common feature of patients with non-alcoholic fatty liver disease (NAFLD). Here, hepatic SR-BI expression was analyzed in human and murine NAFLD. In primary human hepatocytes NAFLD relevant factors like inflammatory cytokines, lipopolysaccharide and TGF-β did not affect SR-BI protein. Similarly, oleate and palmitate had no effect. The adipokines chemerin, adiponectin, leptin and omentin did not regulate SR-BI expression. Accordingly, hepatic SR-BI was not changed in human and murine fatty liver and non-alcoholic steatohepatits. SR-BI was higher in type 2 diabetes patients but not in those with hypercholesterolemia. The current study indicates a minor if any role of SR-BI in human and murine NAFLD.
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Authors
Lisa Rein-Fischboeck, Sabrina Krautbauer, Kristina Eisinger, Rebekka Pohl, Elisabeth M. Meier, Thomas S. Weiss, Christa Buechler,