Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10751860 | Biochemical and Biophysical Research Communications | 2015 | 6 Pages |
Abstract
Here, we identified the multifunctional adaptor protein p62 as a critical regulator in CD40-mediated NFκB signaling via TRAF6. CD40 activation triggered formation of a TRAF6-p62 complex. Disturbing this interaction tremendously reduced CD40-mediated NFκB signaling in macrophages, while TRAF6-independent signaling pathways remained unaffected. This highlights p62 as a potential target in hyper-inflammatory, CD40-associated pathologies.
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Authors
Kristina Seibold, Martin Ehrenschwender,