Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10752702 | Biochemical and Biophysical Research Communications | 2015 | 19 Pages |
Abstract
Fish oil, which contains omega-3 fatty acids mainly in the form of triglycerides, has benefits for reducing breast cancer risk, similar to tamoxifen action. However, it remains to be elucidated whether the combination of omega-3 free fatty acid (Ï-3FFA) with tamoxifen leads to improved treatment in breast cancer. In this study, we observed that Ï-3FFA induces MCF-7 cell apoptosis to suppress cell growth. The treatment of breast cancer cells with Ï-3FFA attenuated tamoxifen-induced cell apoptosis. Ï-3FFA and tamoxifen significantly increased Erk1/2 and Akt phosphorylation levels in a dose and time dependent manner. Compared to Ï-3FFA alone, the combination of tamoxifen with Ï-3FFA significantly increased Erk1/2 and Akt phosphorylation levels. Because Erk1/2 and Akt activation has been linked to tamoxifen-related anti-estrogen resistance in breast cancer patients, these results indicate that Ï-3FFA may interfere with the effects of tamoxifen in the prevention of breast cancer risk.
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Authors
Shufan Wu, Yang Guo, Yikuan Wu, Shenglong Zhu, Zhao He, Yong Q. Chen,