Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10752853 | Biochemical and Biophysical Research Communications | 2015 | 7 Pages |
Abstract
Membrane fusion between host cells and HIV-1 is the initial step in HIV-1 infection, and plasma membrane fluidity strongly influences infectivity. In the present study, we demonstrated that GUT-70, a natural product derived from Calophyllum brasiliense, stabilized plasma membrane fluidity, inhibited HIV-1 entry, and down-regulated the expression of CD4, CCR5, and CXCR4. Since GUT-70 also had an inhibitory effect on viral replication through the inhibition of NF-κB, it is expected to be used as a dual functional and viral mutation resistant reagent. Thus, these unique properties of GUT-70 enable the development of novel therapeutic agents against HIV-1 infection.
Keywords
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Authors
Kouki Matsuda, Shinichiro Hattori, Ryusho Kariya, Yuji Komizu, Eriko Kudo, Hiroki Goto, Manabu Taura, Ryuichi Ueoka, Shinya Kimura, Seiji Okada,