Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10753747 | Biochemical and Biophysical Research Communications | 2014 | 5 Pages |
Abstract
To investigate the association between the polymorphism of P choose element (p. selectin, PS) and soluble P-selectin levels in atrial fibrillation (AF) thromboembolism in Han and Uigur population of Xinjiang. Method: Using ELISA method determination of plasma level of sPs. The frequency distributions of SNP sP-selectin gene promoter (â2123C/G) and SNP in exon region (Thr715Pro) were investigated by polymerase chain reaction (PCR)-restriction fragment length polymorphism and direct DNA sequence analysis among 302 Xinjiang Uigur and 340 age- and sex-matched Han people. Results: Cases sPs exist significant difference serum level and the control group. The frequencies of the â2123C/G allele among the Uigur population had no significant differences from those of the Han population. Thr715Pro did not show any polymorphism in the two populations. Conclusions: The sP-selectin gene polymorphisms are associated with serum sP-selectin levels or thromboembolic events, suggesting that the patients with nonvalvular AF and thromboembolic events may have genetic susceptibility.
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Authors
Ling Bai, Zhiqiang Liu, Maerjiaen Bakeyi, Wuhong Lu, Pengyi He, Yuchun Yang, Muhuyati Wulasihan,