Article ID Journal Published Year Pages File Type
10753825 Biochemical and Biophysical Research Communications 2014 7 Pages PDF
Abstract
Our results indicate that the ROS-induced cellular senescence in NHEKs was caused by the upregulation p16INK4a through demethylation in its promoter region, which is not detected in SCCs, suggesting that ROS-induced cellular senescence contributes to tumor suppression of NHEKs.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16INK4a
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