| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10754234 | Biochemical and Biophysical Research Communications | 2014 | 12 Pages |
Abstract
Our findings reveal the following novel molecular mechanisms controlling mitochondrial fission during A/R injury of cardiomyocytes: (1) ROS are upstream initiators of mitochondrial fission; and (2) the increased mitochondrial fission is resulted from both increased activation and decreased inactivation of Drp1 through Cdk1, PKCδ, and calcineurin-mediated pathways, respectively.
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Authors
Ivan Zaja, Xiaowen Bai, Yanan Liu, Chika Kikuchi, Svjetlana Dosenovic, Yasheng Yan, Scott G. Canfield, Zeljko J. Bosnjak,