| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10754254 | Biochemical and Biophysical Research Communications | 2014 | 7 Pages |
Abstract
HDAC1 blocks canonical Wnt signaling pathway through down-regulating β-catenin at both transcriptional and post-translational levels. At transcriptional level, HDAC1 binds to ctnnb1 promoter and inhibits β-catenin mRNA synthesis. At the post-translational level, HDAC1 binds to β-catenin protein through its deacetylase domain and promotes degradation of β-catenin.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Xiaoju Huang, Jiajia Xu, Mingjian Huang, Jiao Li, Liming Dai, Kerong Dai, Xiaoling Zhang,