Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10754285 | Biochemical and Biophysical Research Communications | 2014 | 7 Pages |
Abstract
The purpose of this study is to determine whether IL-27 regulates macrophage ABCA1 expression, foam cell formation, and also explore the underlying mechanisms. Here, we revealed that IL-27 decreased lipid accumulation in THP-1 derived macrophages through markedly enhancing cholesterol efflux and increasing ABCA1 expression at both protein and mRNA levels. Our study further demonstrated that IL-27 increased ABCA1 level via activation of signal transducer and activator of transcription 3 (STAT3). Inhibition of Janus kinase 2, (JAK2)/STAT3 suppressed the stimulatory effects of IL-27 on ABCA1 expression. The present study concluded that IL-27 reduces lipid accumulation of foam cell by upregulating ABCA1 expression via JAK2/STAT3. Therefore, targeting IL-27 may offer a promising strategy to treat atherosclerotic vascular disease.
Keywords
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Authors
Hui Fu, Yan-yan Tang, Xin-ping Ouyang, Shi-lin Tang, Hua Su, Xiaotao Li, Li-ping Huang, Miao He, Yun-cheng Lv, Ping-ping He, Feng Yao, Yu-lin Tan, Wei Xie, Min Zhang, Jianfeng Wu, Yuan Li, Kong Chen, Dan Liu, Chao-ke Tang,