Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10754472 | Biochemical and Biophysical Research Communications | 2014 | 6 Pages |
Abstract
In conclusion, we here demonstrate for the first time osteoporosis associated alterations in BMP mediated hMSC recruitment. These findings may underlie the reduced healing of osteoporotic fractures. Nevertheless, the maintained migration and invasion response upon BMP stimulation illustrates the therapeutic potential of these clinically approved substances in the treatment of osteoporotic fractures. Another therapeutic target may be the downregulation of the collagen binding integrin α2 in hMSC from osteoporotic patients.
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Authors
Florian Haasters, Denitsa Docheva, Christoph Gassner, Cvetan Popov, Wolfgang Böcker, Wolf Mutschler, Matthias Schieker, Wolf Christian Prall,