Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10754893 | Biochemical and Biophysical Research Communications | 2014 | 24 Pages |
Abstract
Ventricular myosin-S1 (left) consists of a myosin heavy chain (MyHC, light blue) forming the globular motor domain and the a-helical lever arm, which is non-covalently associated with the human ventricular myosin light chain 1(hVLC-1; dark blue) and a regulatory myosin light chain (RLC, turquoise ). Single ventricular myosin molecules showed high stiffness and force generating capacity. Introduction of the E56G mutation into the hVLC-12 (right; hVLC-1E56G) associated with familial hypertrophic cardiomyopathy significantly reduced force myosin stiffness and force generation.
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Authors
Janine Lossie, Clemens Köhncke, Shokoufeh Mahmoodzadeh, Walter Steffen, Monica Canepari, Manuela Maffei, Martin Taube, Oriane Larchevêque, Philipp Baumert, Hannelore Haase, Roberto Bottinelli, Vera Regitz-Zagrosek, Ingo Morano,