Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10755029 | Biochemical and Biophysical Research Communications | 2014 | 6 Pages |
Abstract
Here we established a unique human glial cell line, GDC90, derived from a human glioma and demonstrated its utility as a glial scaffold for the polarization and differentiation of human induced pluripotent stem cell-derived neural progenitor cells (iPSC-NPCs). When co-cultured with GDC90 cells, iPSC-NPCs underwent rapid polarization and neurite extension along the radially spreading processes of the GDC90 cells, and showed migratory behavior. This method is potentially useful for detailed examination of neurites or for controlling neurites behavior for regenerative medicine.
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Authors
Yohei Bamba, Tomoko Shofuda, Daisuke Kanematsu, Masahiro Nonaka, Mami Yamasaki, Hideyuki Okano, Yonehiro Kanemura,