Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10755131 | Biochemical and Biophysical Research Communications | 2014 | 7 Pages |
Abstract
In this study, we induced differentiation of CPT II-deficient hiPSCs into mature myocytes in a highly efficient and reproducible manner and recapitulated some aspects of the disease phenotypes of CPT II deficiency in the myocyte disease models. This approach addresses the challenges of modeling the abnormality of FAO in CPT II deficiency using iPSC technology and has the potential to revolutionize translational research in this field.
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Authors
Tetsuhiko Yasuno, Kenji Osafune, Hidetoshi Sakurai, Isao Asaka, Akihito Tanaka, Seiji Yamaguchi, Kenji Yamada, Hirofumi Hitomi, Sayaka Arai, Yuko Kurose, Yasuki Higaki, Mizuki Sudo, Soichi Ando, Hitoshi Nakashima, Takao Saito, Hidetoshi Kaneoka,