Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10755234 | Biochemical and Biophysical Research Communications | 2014 | 7 Pages |
Abstract
Antitumor antibiotic lidamycin (LDM) is widely used in the treatment of a variety of cancers. Here we demonstrated that LDM up-regulates the expression of the tumor suppressor p53 gene by repressing Oct4 transcription. We showed that low dose LDM-induced increase of p53 expression and decrease of Oct4 expression in P19 and HCT116-p53+/+ cells. Knockdown of Oct4 expression by siRNA led to activation of p53 in both cell lines, whereas ectopical expression of Oct4 significantly inhibited p53 expression in P19 cells. LDM-induced p53 activation was blocked by ectopical expression of Oct4.
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Authors
Hong-Ying Zhen, Juan Zhou, Hou-Nan Wu, Cheng Yao, Ting Zhang, Tong Wu, Cheng-Shi Quan, Yu-Lin Li,