| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10755518 | Biochemical and Biophysical Research Communications | 2014 | 7 Pages |
Abstract
Several disorders in the RyR channel function characteristic of the CPVT-mutant cells (increased spontaneous Ca2+ leak, delayed afterdepolarization, triggered activity, Ca2+ spark frequency, spontaneous Ca2+ transients) can be corrected to a normal function by increasing the affinity of CaM binding to the RyR.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Kato, Wakako Murakami, Akihiro Hino, Makoto Ono, Hiroki Tateishi, Testuro Oda, Shinichi Okuda, Shigeki Kobayashi, Noritaka Koseki, Hiroyuki Kyushiki, Masafumi Yano,