Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10755772 | Biochemical and Biophysical Research Communications | 2014 | 6 Pages |
Abstract
The mechanism by which lutein, a carotenoid, acts as an antioxidant in retinal cells is still not fully understood. Here, lutein treatment of a neuronal cell line (PC12D) immediately resulted in reduced intracellular ROS levels, implying that it has a direct role in ROS scavenging. Significantly, lutein treatment also induced phase II antioxidative enzyme expression, probably via a nuclear factor-like 2 (Nrf2) independent pathway. This latter mechanism could explain why lutein acts diversely to protect against oxidative/cytotoxic stress, and why it is physiologically involved in the human neural tissue, such as the retina.
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Biochemistry
Authors
Seiji Miyake, Saori Kobayashi, Kazuo Tsubota, Yoko Ozawa,