Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10755920 | Biochemical and Biophysical Research Communications | 2014 | 5 Pages |
Abstract
Gastric cancer (GC) is the second common cause of cancer-related death worldwide. microRNAs (miRNAs) play important roles in the carcinogenesis of GC. Here, we found that miR-22 was significantly decreased in GC tissue samples and cell lines. Ectopic overexpression of miR-22 remarkably suppressed cell proliferation and colony formation of GC cells. Moreover, overexpression of miR-22 significantly suppressed migration and invasion of GC cells. CD151 was found to be a target of miR-22. Furthermore, overexpression of CD151 significantly attenuated the tumor suppressive effect of miR-22. Taken together, miR-22 might suppress GC cells growth and motility partially by inhibiting CD151.
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Authors
Xun Wang, Honggang Yu, Xinyao Lu, Peng Zhang, Minglin Wang, Yikui Hu,