Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10756029 | Biochemical and Biophysical Research Communications | 2014 | 5 Pages |
Abstract
NUMB, well-known tumor suppressor gene, is a novel interacting partner of TRPV6. We show that NUMB and TRPV6 have a reciprocal positive regulatory relationship in PC-3 cells. We repeated this experiment in two other prostate cancer cell lines, DU145 and LNCaP. Interestingly, there were no significant changes in TRPV6 expression following NUMB knockdown in DU145. We revealed that the presence or absence of PTEN was the cause of NUMB-TRPV6 function. Loss of PTEN caused a positive correlation of TRPV6-NUMB expression. Collectively, we determined that PTEN is a novel interacting partner of TRPV6 and NUMB. These results demonstrated a novel relationship of NUMB-TRPV6 in prostate cancer cells, and show that PTEN is a novel regulator of this complex.
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Authors
Sung-Young Kim, Chansik Hong, Jinhong Wie, Euiyong Kim, Byung Joo Kim, Kotdaji Ha, Nam-Hyuk Cho, In-Gyu Kim, Ju-Hong Jeon, Insuk So,