Article ID Journal Published Year Pages File Type
10756166 Biochemical and Biophysical Research Communications 2014 6 Pages PDF
Abstract

- Activated SREBP-2 suppresses FGF19 expression in LS174T cells.
- The suppressive effects are dependent on FXR-responsive elements in FGF19 gene.
- SREBP-2 suppresses FXR binding to the FXR-responsive element.
- SREBP-2 directly binds to FXR.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells
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