| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10756475 | Biochemical and Biophysical Research Communications | 2014 | 6 Pages |
Abstract
- Lipid derivatives of cell-penetrating peptides (CPP) were newly synthesized.
- Lipid nanoparticles modified with CPP (CPP-LNP) were designed for siRNA delivery.
- CPP-LNP entered cells by macropinocytosis and heparan sulfate-mediated endocytosis.
- Small interfering RNA encapsulated in CPP-LNP induced specific gene silencing.
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Authors
Tomohiro Asai, Takuma Tsuzuku, Shoya Takahashi, Ayaka Okamoto, Takehisa Dewa, Mamoru Nango, Kenji Hyodo, Hiroshi Ishihara, Hiroshi Kikuchi, Naoto Oku,