| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10756532 | Biochemical and Biophysical Research Communications | 2014 | 4 Pages |
Abstract
- Oxidation of cholesterol and linoleates induced by free radicals yields 7-OHCh and HODE, respectively.
- During free radical-mediated lipid peroxidation in plasma, the amount of HODE was higher than that of 7-OHCh.
- In contrast to plasma oxidation, cellular cholesterol is more susceptible to oxidation than cellular linoleates.
- Cholesterol oxidation products at the 7-position may be a biomarker of cellular lipid peroxidation.
Keywords
PC-OOHSECphosphatidylcholine hydroxideAIPHPLPCHpODECE-OOHGSHGPXPBS2,2′-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride7-Hydroxycholesterol7-KetocholesterolHODEhydroperoxyoctadecadienoic acidhydroxyoctadecadienoic acidPolyunsaturated fatty acidPUFABiomarkerthioredoxin reductaseFree radicalSelenocysteinePhospholipid hydroperoxide glutathione peroxidaselow density lipoproteinLDLPhosphate-buffered salinePhosphatidylcholine hydroperoxidecholesteryl ester hydroperoxidecholesterolGlutathioneglutathione peroxidase
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Authors
Yoshiro Saito, Noriko Noguchi,