| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10756543 | Biochemical and Biophysical Research Communications | 2014 | 7 Pages |
Abstract
- 24S-Hydroxycholesterol is almost absent from brain of the Cyp46a1â/â mouse.
- It is not quantitatively replaced by another oxysterol.
- Minor amounts of 22R-, 24R-, 25- and (25R),26-hydroxycholesterols are present.
- Cholesterol biosynthesis is reduced in brain of the Cyp46a1â/â mouse.
- 24S,25-Epoxycholesterol synthesis is reduced in brain of the Cyp46a1â/â mouse.
Keywords
mass spectrometry or mass spectrumESICyPGirard P reagentSPECYP46A1SCAPRICMRMSREBPTLRMSNLXR24S-hydroxycholesterolSolid phase extractionOxysterolInsigFourier transformToll-like receptorCytochrome P450reversed phaseBrainmultiple reaction monitoringwild typesrebp cleavage-activating proteinInsulin Induced Geneliver X receptorliquid chromatographyReconstructed ion chromatogramelectrospray ionisation
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Authors
Anna Meljon, Yuqin Wang, William J. Griffiths,