Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells

Article ID	Journal	Published Year	Pages	File Type
10756580	Biochemical and Biophysical Research Communications	2014	5 Pages	PDF

Abstract

- The presence of cCMP and cUMP in intact cells is unambiguously documented.
- Soluble guanlyl cyclase generates cCMP and cUMP in intact cells.
- cGMP, cCMP and cUMP show different regulatory patterns.
- Mn2+ is a physiological cofactor for soluble guanylyl cyclase.

Keywords

cGMP uridine 3′,5′-cyclic monophosphate inosine 3′,5′-cyclic monophosphate CTMP cCMP cNMP CIMP PKG pKa PDE cAMP guanosine 3′,5′-cyclic monophosphate adenosine 3′,5′-cyclic monophosphate cUMP cytidine 3′,5′-cyclic monophosphate Phosphodiesterase cAMP-dependent protein kinase cGMP-dependent protein kinase