Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10756918 | Biochemical and Biophysical Research Communications | 2014 | 5 Pages |
Abstract
Microglial activity (evaluated by quantifying AIF1 expression) and gene expression of molecules that modulate microglia, decreased at 6 M, just like the synapse/dendritic spine number. Thus, although microglial activity is believed to be related to phagocytosis of synapses/dendritic spines, microglial activity alone cannot explain how pruning was accelerated in the pruning phase. On the other hand, expression of molecules that tag synapses/dendritic spines as a target of phagocytosis by microglia (e.g., complement components) increased at 6 M, suggesting that these tagging proteins may be involved in the acceleration of pruning during the pruning phase.
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Authors
Tetsuya Sasaki, Tomofumi Oga, Keiko Nakagaki, Kazuhisa Sakai, Kayo Sumida, Kohei Hoshino, Izuru Miyawaki, Koichi Saito, Fumikazu Suto, Noritaka Ichinohe,