| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10757011 | Biochemical and Biophysical Research Communications | 2014 | 6 Pages |
Abstract
These results indicate that DPP-4 inhibitor, PKF275-055, have reno-protective effects through anti-inflammatory action in the early stage of diabetic nephropathy. The endogenous biological active GLP-1 might be beneficial on diabetic nephropathy besides lowering blood glucose.
Keywords
NF-κBGIPGLP-1DPP-4ICAM-1PAMTGF-βcyclic AMPcAMPSprague–Dawleyinflammationinterleukintransforming growth factor-βtumor necrosis factor-αcluster of differentiationDipeptidyl peptidase-4TNF-αnuclear factor-κBMacrophageDipeptidyl peptidase-4 inhibitorintercellular adhesion molecule-1Diabetic nephropathygastric inhibitory polypeptideC-reactive proteinCRPglucagon-like peptide-1
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Authors
Ryo Kodera, Kenichi Shikata, Tetsuharu Takatsuka, Kaori Oda, Satoshi Miyamoto, Nobuo Kajitani, Daisho Hirota, Tetsuichiro Ono, Hitomi Kataoka Usui, Hirofumi Makino,