| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10757045 | Biochemical and Biophysical Research Communications | 2014 | 6 Pages |
Abstract
- The serum transporter SePP supplies selenium (Se) to testes for GPX4 biosynthesis.
- Testes and GPX4 are preferentially supplied making them selenium-independent.
- We find SePP in seminal plasma as a stable biomarker correlating to sperm vitality.
- Seminal SePP does not originate in testes but in Se-responsive accessory sex glands.
- Besides transport, SePP likely protects sperm as a powerful antioxidative enzyme.
Keywords
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Biochemistry
Authors
Marten Michaelis, Oliver Gralla, Thomas Behrends, Marcus Scharpf, Tobias Endermann, Eddy Rijntjes, Nicole Pietschmann, Birgit Hollenbach, Lutz Schomburg,