Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10757086 | Biochemical and Biophysical Research Communications | 2014 | 6 Pages |
Abstract
We found that the concentration of 4-HHE (a product of n-3 PUFAs peroxidation) and expression of HO-1 mRNA were significantly increased after fish-oil treatment in most tissues. In addition, these increases were paralleled by an increase in the level of docosahexaenoic acid (DHA) but not eicosapentaenoic acid (EPA) in each tissue. These results are consistent with our previous results showing that DHA induces HO-1 expression through 4-HHE in vascular endothelial cells. In conclusion, we hypothesize that the HO-1-mediated protective effect of the fish oil diet may be through production of 4-HHE from DHA but not EPA in various tissues.
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Authors
Fumiyuki Nakagawa, Katsutaro Morino, Satoshi Ugi, Atsushi Ishikado, Keiko Kondo, Daisuke Sato, Shiho Konno, Ken-ichi Nemoto, Chisato Kusunoki, Osamu Sekine, Akihiro Sunagawa, Masanori Kawamura, Noriko Inoue, Yoshihiko Nishio, Hiroshi Maegawa,