Article ID Journal Published Year Pages File Type
10757119 Biochemical and Biophysical Research Communications 2014 6 Pages PDF
Abstract

- Accumulation of Aβ plaques is one of the major pathology associated with Alzheimer's disease.
- Inhibition of β-Secretase or BACE-1 offers a viable prospect to check the growth of these plaques.
- A large virtual dataset of natural compounds was screened against BACE-1.
- Top two hits were analyzed for thermodynamic & structural stability using MD simulations.
- Their detailed binding mode of actions were elucidated.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Mechanistic insights into mode of action of potent natural antagonists of BACE-1 for checking Alzheimer's plaque pathology
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