Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10757194 | Biochemical and Biophysical Research Communications | 2013 | 5 Pages |
Abstract
In order to obtain compounds with modified 2-APB activities, we synthesized number of 2-APB analogues and analyzed their inhibitory activities for SOCE. The IC50 of 2-APB for SOCE inhibition is 3 μM while IC50 of some of our 2-APB analogues range 0.1-10 μM. The adducts of amino acids with diphenyl borinic acid have strong inhibitory activities. By using these compounds, we will be able to regulate intracellular Ca2+ concentration and consequent cellular processes more efficiently than with 2-APB.
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Authors
Shoichiro Ozaki, Akinobu Z. Suzuki, Peter O. Bauer, Etsuko Ebisui, Katsuhiko Mikoshiba,