Article ID Journal Published Year Pages File Type
10757472 Biochemical and Biophysical Research Communications 2014 7 Pages PDF
Abstract

- EpCAM is heterogeneously expressed in prostate cancer both in vitro and in vivo.
- mTOR signaling is differentially regulated in EpCAM-high and -low subpopulations.
- EpCAM induces the susceptibility to EGF ligand and sustained EGFR activation.
- There is a positive correlation between EpCAM and LAT1 expression.
- EpCAM works as a sensor for the available growth factors to activate AMPK signal.
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