Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10757473 | Biochemical and Biophysical Research Communications | 2014 | 6 Pages |
Abstract
TNFα down-modulated miR-149 level in Eahy926 and HUVEC. This effect was significantly abolished in Eahy926 by treatment with p38MAPK inhibitor. miR-149 mimic transfection counteracted the TNFα-induced expression of MMP-9, iNOS and IL-6. No effect was detected on IL-8 expression. Our results suggest that miR-149 represents an important new regulator of endothelial function through negative regulation of molecules associated with TNFα-induced endothelial dysfunction.
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Authors
Daniela Palmieri, Simona Capponi, Alessandro Geroldi, Marzia Mura, Paola Mandich, Domenico Palombo,