Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10757539 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
- The structure of the oxidized A-domain of human HMGB1 was solved.
- Phe38 ring was flipped in the oxidized structure from that in the reduced form.
- The flipped ring disables the intercalation into the cisplatinated lesions.
- The functionally relevant redox-dependent structural change was described.
Keywords
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Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Jing Wang, Naoya Tochio, Aya Takeuchi, Jun-ichi Uewaki, Naohiro Kobayashi, Shin-ichi Tate,