Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10757589 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
In the present study, we investigated whether a histone deacetylase sirtuin 1 (SIRT1) can regulate the protein stability of homeodomain-interacting protein kinase 2 (HIPK2). We observed the evidence of molecular interaction between SIRT1 and HIPK2. Interestingly, overexpression or pharmacological activation of SIRT1 promoted ubiquitination and the proteasomal degradation of HIPK2 whereas inhibition of SIRT1 activity increased the protein level of HIPK2. Furthermore, a SIRT1 activator decreased the level of HIPK2 acetylation whereas an inhibitor increased the acetylation level. These results suggest that SIRT1 may deacetylate and promote the ubiquitination and subsequent proteasomal degradation of HIPK2.
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Authors
Joohyun Hwang, Seo-Young Lee, Jong-Ryoul Choi, Ki Soon Shin, Cheol Yong Choi, Shin Jung Kang,