Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10757701 | Biochemical and Biophysical Research Communications | 2013 | 5 Pages |
Abstract
Apoptotic death of virus-infected cells is generally thought to be a defense mechanism to limit the spread of infectious virions by eliminating virus-producing cells in host animals. On the other hand, several viruses have been shown to have anti-apoptotic mechanisms to facilitate efficient viral replication and transmission. In this study, we found that the filovirus glycoprotein (GP) expressed on cell surfaces formed a steric shield over the Fas molecule and that GP-expressing cells showed resistance to cell death induced by a Fas agonistic antibody. These results suggest that filovirus GP-mediated steric shielding may interfere with the Fas-induced apoptotic signal transduction in infected cells and serve as an immune evasion mechanism for filoviruses.
Keywords
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Authors
Osamu Noyori, Eri Nakayama, Junki Maruyama, Reiko Yoshida, Ayato Takada,