| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10757956 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
- Inhibitors against MDR HIV-1 protease were designed, synthesized and evaluated.
- Lead peptide (6a) showed potent inhibition (IC50: 4.4Â nM) of MDR HIV-1 protease.
- (6a) Showed favorable binding isotherms against NL4-3 and MDR proteases.
- (6a) Induced perturbations in the 15N-HSQC spectrum of MDR HIV-1 protease.
- Molecular modeling suggested that (6a) may induce total flap closure inMDR protease.
Keywords
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Authors
Ravikiran S. Yedidi, Joseck M. Muhuhi, Zhigang Liu, Krisztina Z. Bencze, Kyriacos Koupparis, Carrie E. O'Connor, Iulia A. Kovari, Mark R. Spaller, Ladislau C. Kovari,