Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo

- Thymoquinone inhibits phorbol ester-induced COX-2 expression in mouse skin.
- Thymoquinone attenuates phosphorylation of IκBα and DNA binding of NF-κB in mouse skin.
- Thymoquinone inhibits phosphorylation of p38 MAP kinase, JNK and Akt in mouse skin.
- Thymoquinone induces the expression of cytoprotective proteins in mouse skin.