| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10758082 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
- LOX-1 is the major receptor for oxidized low-density lipoprotein.
- A new LOX-1 inhibitor, named PLAzPC, has been synthesized.
- The compound has been designed to recognize the LOX-1 hydrophobic tunnel.
- Docking analysis indicates high affinity of PLAzPC toward the receptor tunnel.
- Cell-based binding assays confirm the inhibitory activity of the novel compound.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Mattia Falconi, Sarah Ciccone, Paola D'Arrigo, Fiorenza Viani, Roberto Sorge, Giuseppe Novelli, Patrizia Patrizi, Alessandro Desideri, Silvia Biocca,