| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10758287 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
Cardiac-specific overexpression of SMP30 inhibited angiotensin II-induced cardiac adverse remodeling. SMP30 has a cardio-protective role with anti-oxidative and anti-aging effects and could be a novel therapeutic target to prevent cardiac hypertrophy and remodeling due to hypertension.
Keywords
LVWearly diastolic mitral annular velocityTibial lengthSMP30SA-β-galIVSLVEDdLVESDE′senescence-associated β-galactosidaseAngiotensin IILeft ventricular end-diastolic dimensionCardiac remodelingLeft ventricular end-systolic dimensionOxidative stressdihydroethidiumAgingposterior wall thicknessTransgenic mouseDHEbody weightleft ventricular weightHeart weightsenescence marker protein 30left ventricular fractional shorteninga′
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Authors
Tomofumi Misaka, Satoshi Suzuki, Makiko Miyata, Atsushi Kobayashi, Akihito Ishigami, Tetsuro Shishido, Shu-ichi Saitoh, Isao Kubota, Yasuchika Takeishi,