Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10758408 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
- Mitochondria dysfunction and oxidative stress are thought to cause insulin resistance.
- High fat feeding causes glucose intolerance in mice and promotes lipid oxidation in tissues.
- Increased Sod1 or Sod2 prevented obesity-induced glucose intolerance and lipid oxidation.
- No change in mitochondrial function in muscle from high fat fed mice.
- Increased Sod1, but not Sod2, reduced mitochondrial ROS and increased ATP production.
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Authors
Yuhong Liu, Wenbo Qi, Arlan Richardson, Holly Van Remmen, Yuji Ikeno, Adam B. Salmon,