Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10758536 | Biochemical and Biophysical Research Communications | 2013 | 5 Pages |
Abstract
The results show the first evidence that calreticulin: (1) is localized outside the ER on the cell surface of HFC; (2) coimmunoprecipitates with Cav1.3 L-type Ca channel; (3) negatively regulates Cav1.3 surface expression thus resulting in decreased Cav1.3 Ca current densities. The data demonstrate a novel mechanism of modulation of Cav1.3 Ca channel by calreticulin, which may be involved in pathological settings such as autoimmune associated congenital heart block where Cav1.3 Ca channels are downregulated.
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Authors
Eddy Karnabi, Yongxia Qu, Yunkun Yue, Mohamed Boutjdir,