| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10759018 | Biochemical and Biophysical Research Communications | 2013 | 5 Pages |
Abstract
- We designed, synthesized and studied a new bivalent D-peptide antagonist of CXCR4.
- This peptide shows very high binding affinity for CXCR4.
- This peptide inhibits calcium influx and cancer cell migration triggered by SDF-1α.
- This peptide inhibits HIV-1 infection and is not cytotoxic.
- This peptide is a new probe of CXCR4 function and lead for therapeutic development.
Keywords
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Biochemistry
Authors
Yan Xu, Srinivas Duggineni, Stephen Espitia, Douglas D. Richman, Jing An, Ziwei Huang,