| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10759155 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
- Ribavirin triphosphate (RTP) targets eIF4E in patients and human cells.
- NMR studies indicate RTP binds eIF4E in the m7G cap binding pocket.
- Features of RTP recognition overlap with, but are distinct from, the m7G cap.
- High and low affinity eIF4E-RTP complexes reveal structural differences.
- Considerations for drug design and new insights into ligand recognition.
Keywords
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Authors
Laurent Volpon, Michael J. Osborne, Hiba Zahreddine, Andrea A. Romeo, Katherine L.B. Borden,