| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10759264 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
We also showed that the expression of Cdx2 is induced in ESCs by forced H19 expression even under a high level of Oct3/4, which could act as a suppressor for Cdx2 expression. It is thus suggested that the H19 induction promotes trophoblast lineage commitment against the repression pressure by Oct3/4 in differentiating ESCs. Taken together, this study suggests that the H19 expression is able to function as a cascade activator of trophoblast lineage commitment possibly by overriding the Oct3/4 action in ESCs.
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Authors
Hiroaki Fujimori, Hiroaki Mukai, Yasufumi Murakami, Myriam Hemberger, Yoshitaka Hippo, Mitsuko Masutani,