Article ID Journal Published Year Pages File Type
10759441 Biochemical and Biophysical Research Communications 2013 6 Pages PDF
Abstract
Cdx1 exerts a protective role in colon cancer stem cells, which play a crucial role in chemoresistance to paclitaxel through activation of autophagy. Autophagy is activated though the Cdx1-Bcl-2-LC3 pathway. In contrast, p53 exerts a major role in apoptosis and inhibits autophagy in colon cancer stem cells.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells
Authors
, , , ,