| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10759467 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
Behcet's disease (BD) is a chronic relapsing inflammatory autoimmune disease characterized by recurrent oral and genital ulcers, skin legions and uveitis and its pathogenesis is not fully elucidated. Previously we identified that two novel susceptible SNPs are associated with BD. One is located in putative RNF39 promoter region, another is located on TRIM39 coding exon. In this study, in order to identify the molecular function of TRIM39, we established gain-of-function of TRIM39 related genes and thus, performed microarray analysis. Our results indicate that TRIM39R, but not TRIM39B, regulates type I interferon response.
Keywords
OASSPVDFFDRHEKIRFsType I interferon responseIFISTRIMTBSTcRNAAPC/CISGscomplementary RNATris-buffered saline containing 0.1% Tween-20Human leukocyte antigenHLAInterferon stimulated genesinterleukinBehçet’s diseasepolyvinylidene difluorideLinkage disequilibriuminterferon regulatory factorsGenome-wide association studyGWASfalse discovery rateanaphase-promoting complexhuman embryonic kidney
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Authors
Riho Kurata, Atsushi Tajima, Tomo Yonezawa, Hidetoshi Inoko,