Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10759470 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
Chemotherapy frequently results in neurocognitive deficits that include impaired learning and memory. Thus, it is important to prevent or ameliorate the persistence of cognitive impairment. Compound K was employed to examine the ameliorating effect on chronic treatment with cyclophosphamide. Eight week-old ICR mice were given 80Â mg/kg cyclophosphamide, cyclophosphamide combined with compound K (2.5, 5 and 10Â mg/kg) or saline injections once per week for 4Â weeks. Passive avoidance test and Y maze were used to evaluate memory and learning ability. Immunohistochemical staining for progenitor cell and immature neurons was used to assess changes in neurogenesis. Compound K (Â 10 mg/kg) is able to ameliorate the decrease of neurogenesis in the hippocampus caused by cyclophosphamide. These results suggest that compound K might be a potential strategy to ameliorate or repair the disrupted hippocampal neurogenesis induced by the side effect of chemotherapy agent.
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Authors
Jin-gang Hou, Jian-jie Xue, Mi-ra Lee, Meng-qi Sun, Xing-hua Zhao, Yi-nan Zheng, Chang-keun Sung,