Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10759499 | Biochemical and Biophysical Research Communications | 2013 | 5 Pages |
Abstract
We conclude that lithium chloride abolishes the injurious [Ca2+]i overload in EC and that this most likely occurs by preventing inositol 3-phosphate-sensitive Ca2+-release from the endoplasmic reticulum. Though further research is needed, these findings provide a novel option for therapeutic strategies to protect the endothelium against imminent barrier failure.
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Authors
Bert Bosche, Matthias Schäfer, Rudolf Graf, Frauke V. Härtel, Ute Schäfer, Thomas Noll,