| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10759667 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
⺠Arf is required for p53-dependent down-regulation of H2AX and cellular quiescence. ⺠Wild-type MEFs do not immortalize during Arf/p53-dependent quiescence. ⺠Tetraploidization is required for immortalization of wild-type MEFs. ⺠Tetraploidization is dispensable for immortalization of Arf/p53-mutated MEFs. ⺠Arf/p53-mutated MEFs often undergo mitotic catastrophe-associated cell death.
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Authors
Tomoyuki Osawa, Yuko Atsumi, Eiji Sugihara, Hideyuki Saya, Masamoto Kanno, Fumio Tashiro, Mitsuko Masutani, Ken-ichi Yoshioka,