Article ID Journal Published Year Pages File Type
10759740 Biochemical and Biophysical Research Communications 2013 6 Pages PDF
Abstract
► Chimpanzees, horses and humans have regions of similarity on TLR4 and MD2 promoters. ► Rodents have few regions of similarity on TLR4 promoter when compared to primates. ► Conserved NFkB binding sites were found in the promoters of TLR4 and MD2. ► LPS-induced inhibition of TLR4 transcription is reversed by dexamethasone. ► LPS-induced transcription of MD2 is inhibited by dexamethasone.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Lipopolysaccharide-induced inhibition of transcription of tlr4 in vitro is reversed by dexamethasone and correlates with presence of conserved NFκB binding sites
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