Article ID Journal Published Year Pages File Type
10759743 Biochemical and Biophysical Research Communications 2013 6 Pages PDF
Abstract
► We used patch-clamping to study voltage-independent inhibition of CaV2.2 channels. ► We changed PIP2 concentration by internal dialysis and a voltage-sensitive phosphatase (VSP). ► Voltage-independent inhibition requires PLC and it is prevented by exogenous PIP2. ► Voltage-independent inhibition is sensitive to enzymes affecting PIP2 resynthesis. ► PIP2 hydrolysis accounts to the voltage-independent inhibition of CaV2.2 channels.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
PIP2 hydrolysis is responsible for voltage independent inhibition of CaV2.2 channels in sympathetic neurons
Authors
, , , , ,